Darran Jones

Publications

• Positive Functional Synergy of Structurally Integrated, Designed Artificial Protein Dimers Assembled by Fully Genetically Encoded Click Chemistry
• Site-Specific Protein Covalent Attachment to Nanotubes and Its Electronic Impact on Single Molecule Function
• Switching protein metalloporphyrin binding specificity by design from iron to fluorogenic zinc
• The Crystal Structure of Bacillus cereus HblL1
• Differential Bio‐Optoelectronic Gating of Semiconducting Carbon Nanotubes by Varying the Covalent Attachment Residue of a Green Fluorescent Protein
• Design and Characterisation of an Artificial DNA-Binding Cytochrome
• Structure-Guided Engineering of a Family IV Cold-Adapted Esterase Expands Its Substrate Range
• Structure and dynamics of a cold-active esterase reveals water entropy and active site accessibility as the likely drivers for cold-adaptation
• Site-Specific Protein Covalent Attachment to Nanotubes and Its Electronic Impact on Single Molecule Function
• Controlling Self-Assembly by Linking Protein Folding, DNA Binding, and the Redox Chemistry of Heme
• Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes
• Quantitative Imaging of B1 Cyclin Expression Across the Cell Cycle Using Green Fluorescent Protein Tagging and Epifluorescence
• Optimising CNT-FET Biosensor Design: Predictive Modelling of Biomolecular Electrostatic Gating and its Application to Beta-Lactamase Detection
• Histidine-assisted reduction of arylnitrenes upon photo-activation of phenyl azide chromophores in GFP-like fluorescent proteins
• Fabrication and Functionalisation of Nanocarbon‐Based Field‐Effect Transistor Biosensors
• Precision Templated Bottom-Up Multiprotein Nanoassembly through Defined Click Chemistry Linkage to DNA
• Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle
• Site-Specific One-to-One Click Coupling of Single Proteins to Individual Carbon Nanotubes: A Single-Molecule Approach
• Defined covalent assembly of protein molecules on graphene using a genetically encoded photochemical reaction handle
• Excitation-Energy-Dependent Molecular Beacon Detects Early Stage Neurotoxic Aβ Aggregates in the Presence of Cortical Neurons
• Switching metalloporphyrin binding specificity of a b-type cytochrome to fluorogenic zinc by design
• The effect of proximity on the function and energy transfer capability of fluorescent protein pairs
• Better together: building protein oligomers naturally and by design
• Site-Specific Protein Photochemical Covalent Attachment to Carbon Nanotube Side Walls and Its Electronic Impact on Single Molecule Function
• Stalling chromophore maturation of the fluorescent protein Venus reveals the molecular basis of the final oxidation step
• Structure guided engineering of a cold active esterase expands substrate range though a stabilisation mutation that allows access to a buried water chamber
• DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids
• Optimising CNT-FET biosensor design through modelling of biomolecular electrostatic gating and its application to β-lactamase detection
• Molecular dynamics guided engineering of Aequorea victoria Green Fluorescent Protein chromophore interactions generates a brighter variant with improved photobleaching resistance
• Molecular dynamics guided engineering ofAequorea victoriaGreen Fluorescent Protein chromophore interactions generates a brighter variant with improved photobleaching resistance
• Molecular dynamics guided identification of a brighter variant of superfolder Green Fluorescent Protein with increased photobleaching resistance
• Chromophore charge-state switching through copper-dependent homodimerisation of an engineered green fluorescent protein.
• Chromophore charge-state switching through copper-dependent homodimerisation of an engineered green fluorescent protein
• Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification
• Low-temperature plasmonically enhanced single-molecule spectroscopy of fluorescent proteins
• Comparison of the measurement performance of high precision multi-axis metal cutting machine tools
• Editorial: Fiat lux! Light-driven and light-controlled synthetic biological parts, devices, systems and processes
• Random single amino acid deletion sampling unveils structural tolerance and the benefits of helical registry shift on GFP folding and structure
• Association of Fluorescent Protein Pairs and Its Significant Impact on Fluorescence and Energy Transfer
• Stalling chromophore synthesis of the fluorescent protein Venus reveals the molecular basis of the final oxidation step
• Fluorescent Proteins: Crystallization, Structural Determination, and Nonnatural Amino Acid Incorporation
• ΔFlucs: Brighter Photinus pyralis firefly luciferases identified by surveying consecutive single amino acid deletion mutations in a thermostable variant
• Designed Artificial Protein Heterodimers With Coupled Functions Constructed Using Bio-Orthogonal Chemistry
• Erratum: Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification(Chemical Science (2015) 6(3712-3717))
• Aryl azide photochemistry in defined protein environments
• Site-specific protein covalent attachment to nanotube side walls and its electronic impact on single molecule function.
• Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry
• Author Correction: Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry (Communications Chemistry, (2019), 2, 1, (83), 10.1038/s42004-019-0185-5)
• Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices
• Directed evolution of GFP with non-natural amino acids identifies residues for augmenting and photoswitching fluorescence
• Single molecule DNA origami nanoarrays with controlled protein orientation
• Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein
• Different photochemical events of a genetically encoded phenyl azide define and modulate GFP fluorescence
• Glycosylation increases active site rigidity leading to improved enzyme stability and turnover
• A Proofreading Mutation with an Allosteric Effect Allows a Cluster of SARS-CoV-2 Viruses to Rapidly Evolve
• N-linked glycosylation increases horse radish peroxidase rigidity leading to enhanced activity and stability
• Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism
• Transposon-based approaches for generating novel molecular diversity during directed evolution
• Low-temperature plasmonically enhanced single-molecule spectroscopy of fluorescent proteins
• Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein
• Fabrication and Functionalisation of Nanocarbon-Based Field-Effect Transistor Biosensors
• Approaches to single-molecule studies of metalloprotein electron transfer using scanning probe-based techniques
• In-frame amber stop codon replacement mutagenesis for the directed evolution of proteins containing non-canonical amino acids: Identification of residues open to bio- orthogonal modification
• Differential Bio-Optoelectronic Gating of Semiconducting Carbon Nanotubes by Varying the Covalent Attachment Residue of a Green Fluorescent Protein
• Dna-directed assembly of carbon nanotube–protein hybrids
• Cloning, expression and in silico studies of a serine protease from a marine actinomycete (Nocardiopsis sp. NCIM 5124)
• Engineering the specificity of lipoyl domains from the 2-OXO acid dehydrogenase complexes of£. coli
• The origin of serum deoxycytidylate deaminase in disease
• Recombining low homology, functionally rich regions of bacterial subtilisins by combinatorial fragment exchange
• Restricted motion of the lipoyl-lysine swinging arm in the pyruvate dehydrogenase complex of Escherichia coli
• Source of the pregnancy serum N acetyl β glucosaminidase isoenzyme during human pregnancy
• Single-molecule mapping of long-range electron transport for a cytochrome b562 variant
• Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family
• Serum deoxycytidylate deaminase activity after myocardial infarction
• Linking the functions of unrelated proteins using a novel directed evolution domain insertion method
• Structural determinants of post-translational modification and catalytic specificity for the lipoyl domains of the pyruvate dehydrogenase multienzyme complex of Escherichia coli
• The Estimation of Serum Guanosine Deaminase Activity in Liver Disease,Bestimmung von Guanosindesaminase im Serum bei Lebererkrankungen
• Design and characterisation of an artificial DNA-binding cytochrome
• Redox tuning of cytochrome b562 through facile metal porphyrin substitution
• Investigating protein structural plasticity by surveying the consequence of an amino acid deletion from TEM-1 β-lactamase
• Activity of serum cytidine deaminase during pregnancy
• Controlling self-assembly by linking protein folding, DNA binding, and the redox chemistry of heme
• Structural basis for efficient chromophore communication and energy transfer in a constructed didomain protein scaffold
• PLASMA URATE AND SERUM DEOXYCYTIDYLATE DEAMINASE MEASUREMENTS FOR THE EARLY DIAGNOSIS OF PRE‐ECLAMPSIA
• The role of loop and β-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex
• Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx)
• Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes.
• Triplet nucleotide removal at random positions in a target gene: The tolerance of TEM-1 β-lactamase to an amino acid deletion
• Crystal Structure of Enhanced Green Fluorescent Protein to 1.35 Å Resolution Reveals Alternative Conformations for Glu222
• The serum activity of glucose 6 phosphate and 5' nucleotidase during human pregnancy
• The role of loop and β-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex (Biochemistry (2008) 409, (357-366))
• Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism
• Multiple molecular forms of γ glutamyl transpeptidase during human pregnancy
• Regulation of β-lactamase activity by remote binding of heme: Functional coupling of unrelated proteins through domain insertion
• Fast electron transfer through a single molecule natively structured redox protein
• Residue choice defines efficiency and influence of bioorthogonal protein modification via genetically encoded strain promoted Click chemistry
• Recognition of the lipoyl domain is the ultimate determinant of substrate channelling in the pyruvate dehydrogenase multienzyme complex
• Serum deoxycytidylate deaminase as an index of high‐risk pregnancy
• Orientation-dependent electron transport in a single redox protein
• Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
• Genetically encoding phenyl azide chemistry: New uses and ideas for classical biochemistry
• Plasma urate and serum deoxycytidylate deaminase measurements for the early diagnosis of pre-eclampsia
• A Surface Loop Directs Conformational Switching of a Lipoyl Domain Between a Folded and a Novel Misfolded Structure
• The role of substrate specificity and metal binding in defining the activity and structure of an intracellular subtilisin
• Expanded chemical diversity sampling through whole protein evolution
• Direct binding of a redox protein for single-molecule electron transfer measurements
• Environmental dipolar relaxation during excited state proton transfer in Green Fluorescent Protein
• Structure, function and dynamics of mCoral, a pH responsive engineered variant of the mCherry fluorescent protein with improved hydrogen peroxide tolerance.
• Structure, function and dynamics of mCoral, a pH responsive engineered variant of the mCherry fluorescent protein with improved hydrogen peroxide tolerance
• Structure, Function and Dynamics of mCoral, a pH-Responsive Engineered Variant of the mCherry Fluorescent Protein with Improved Hydrogen Peroxide Tolerance