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Summary statistics for Alzheimer's disease GWAS on APOE-e4 homozygous individuals in UK Biobank
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posted on 2024-09-18, 11:33 authored by Matthew Bracher-SmithMatthew Bracher-Smith, Ganna LeonenkoGanna Leonenko, Emily Baker, Karen CrawfordKaren Crawford, Andrew Graham, Dervis Salih, Brian Howell, John Hardy, Valentina Escott-PriceValentina Escott-PriceWe conducted a genome-wide association study in a sample of 5,390 APOE-ε4 homozygous (ε4ε4) individuals (288 cases and 5,102 controls) aged 65 or over in the UK Biobank. Results are the summary statistics from a GWAS conducted in Plink using age, sex and the first 15 principal components as covariates.
There are 5,349,830 rows and 9 columns. Each row corresponds to a variant. Columns are: CHR, BP, SNP, A1, A2_counted_allele, OR, SE_beta, Z_STAT and P. As indicated by column names, A2 is the risk allele counted in the regression. Dataset is gzipped and tab-delimited.
Funding
Genetics collaboration with Prof Bart De Strooper UK DRI programme (2021-05-01 - 2024-06-30); Escott-Price, Valentina. Funder: UK DRI Ltd
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- English-Great Britain (EN-GB)
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