N-Heterocyclic Carbene Acyl Anion Organocatalysis by Ball-Milling

The data here contains a selection of 1H, 13C, 19F NMR data, as well as IR, MS and any relevant chromatography information. Some files may be processed in advance and deposited and some may require access to typical processing tools for data of this type.
Abstract: The ability to conduct N-Heterocyclic carbene catalysed acyl anion chemistry under ball-milling conditions is reported for the first time. This process has been exemplified through applications to intermolecular-benzoin, intramolecular-benzoin, intermolecular- Stetter and intramolecular-Stetter reactions including asymmetric examples and demonstrates that this mode of mechanistically complex organocatalytic reaction can operate under solvent minimised conditions.

Reserach results based upon these data are published at https://doi.org/10.1002/cssc.201902346