Iron-catalyzed methylation using the borrowing hydrogen approach

<p>A general iron-catalyzed methylation has been developed using methanol as a sustainable C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).</p><p>Analysis of reaction products from this methodology resulted in the following data:</p><p>1H, 19F and 13C NMR raw data files</p><p>IR spectra</p><p>High resolution mass spectrometry spectra.   </p><p>Research results based upon these data are published at http://dx.doi.org/10.1021/acscatal.8b02158<br></p>