Cardiff University
Browse

Hippocampal Blood Flow after Twenty Minutes of Moderate-intensity Exercise

Download (18.68 MB)

In this study we investigated whether a single session of moderate-intensity exercise was sufficient to induce changes in the cerebral vasculature using magnetic resonance imaging (MRI). We employed arterial spin labelling MRI to measure global and regional cerebral blood flow and arterial transit time before and after 20-minutes of cycling in healthy adults with 3 post-exercise timepoints (post1, post2, post3). The blood vessels’ ability to dilate, measured by cerebrovascular reactivity (CVR) to CO2inhalation, was measured at baseline and 25-minutes post-exercise. 

Along with the raw ASL data at baseline and at the 3 post-exercise timepoints,  whole brain cerebral blood flow maps, arterial transit time maps, CVR maps, and R2 maps showing the CVR fitting to CO2 are provided; for each map type, 4 images  are provided for each participant (n=32) for the 4 separate timepoints (baseline, post1, post2, post3). Bash scripts and Matlab code used for the pre-processing of the dataset are provided and R code and bash scripts show the statistical analysis undertaken. A README.txt file details which order the various scripts should be run in to produce the whole-brain maps. 

Research results based upon these data are published at  https://doi.org/10.1093/cercor/bhz104


Funding

Assessing the health of ageing blood vessels in the brain using fMRI (2016-09-01 - 2022-05-15); Murphy, Kevin. Funder: Wellcome Trust

History

Specialist software required to view data files

MRI data visualisation software (e.g. AFNI, FSLview) R to view statistical analysis code in r Matlab

Usage metrics

    School of Medicine

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC