Exploring tandem ruthenium-catalyzed hydrogen transfer and SNAr chemistry

A hydrogen transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield) has been explored. Taking advantage of the hydrogen transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High Resolution Mass Spectrometry spectra

Research results based upon these data are published at http://dx.doi.org/10.1021/acs.orglett.7b03441