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Electrochemical Deconstructive Functionalization of Cycloalkanols via Alkoxy Radicals Enabled by Proton-Coupled Electron Transfer - data

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posted on 2024-10-30, 07:32 authored by Mishra Deepak Hareram, Albara El Gehani, James HarnedyJames Harnedy, Alex SeastramAlex Seastram, Andrew JonesAndrew Jones, Matthew Burns, Thomas WirthThomas Wirth, Duncan Browne

Herein, we report a new electrochemical method for alkoxy radical generation from alcohols using a proton-coupled electron transfer (PCET) approach, showcased via the deconstructive functionalization of cycloalkanols. The electrochemical method is applicable across a diverse array of substituted cycloalkanols, accessing a broad range of synthetically useful distally functionalized ketones. The orthogonal derivatization of the products has been demonstrated through chemoselective transformations, and the electrochemical process has been performed on a gram scale in continuous single-pass flow.

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High resolution mass spectrometry spectra.


Research results based upon these data are published at https://doi.org/10.1021/acs.orglett.2c01552

Funding

Developing continuous electro organic catalysis - it's got potential (2017-11-27 - 2022-01-31); Morrill, Louis. Funder: Engineering and Physical Sciences Research Council

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