Data underpinning "N-Cyanation of Secondary Amines using Trichloroacetonitrile"

A one-pot N-cyanation of secondary amines has been developed using trichloroacetonitrile as an inexpensive cyano source. A diverse range of cyclic and acyclic secondary amines can be readily transformed into the corresponding cyanamides in good isolated yields, with the method successfully utilised in the final synthetic step of a biologically-active rolipram-derived cyanamide. This approach exhibits distinct selectivity when compared to the use of highly toxic cyanogen bromide.

Herein we include all underpinning data for this publication, including:

    1H, 19F and 13C NMR raw data files
    IR spectra
    HRMS spectra

Research results based upon these data are published at http://10.1021/acs.orglett.6b02775