Data for Primary Visual Cortex Physiology and Function in a Mouse Model of Timothy Syndrome, Craddock et al.

Primary Visual Cortex Physiology and Function in a Mouse Model of Timothy Syndrome

Rosie Craddock, Cezar M. Tigaret and Frank Sengpiel

DOI: 10.1093/cercor/bhaf162

Data are deposited in subdirectories with the names of the figures and table that the datasets relate to, as follows:

Data repository/fig 1 & table 1/MasterTable Fig1 & Table 1.xlsx

Related to table 1 and Fig 1.

Resting membrane properties (sag & rebound amplitudes as percentage of steady-state membrane potential; input resistance - "Rin"; membrane capacitance; membrane time constant - "Tau"), and action potential (AP) firing parameters (threshold potential; AP duration at half-maximum - "AP Half width"; initial AP firing frequency as the reciprocal of the first inter-spike interval - "ISI_0 freq"; mean AP frequency; minimum AP firing latency; rheobase; maximum rates of AP upstroke and decay - MaxRoR, MaxRoD; fast after-hyperpolarizing potential amplitude and duration - "fAHP amplitude", "fAHP duration"; AP rise (upstroke) and decay times) for the cells in visual cortex area V1, grouped by genotype.

Summary statistics are given below each genotype group.

Data repository/figs 2, 3 & 4/masterDF_minContrastResponsesAllCells.csv

Spatial frequency (SF) and Minimum contrast response data for V1 cells; related to Figs 2, 3, 4.

Data repository/figs 2, 3 & 4/InVivoPlots.R

R script for creating the plots in Figs 2, 3 & 4 using the data in the "masterDF_minContrastResponsesAllCells.csv" file.

Data repository/fig 5/PV CellCount V1.xlsx

Parvalbumin-positive (PV⁺) cell count and fractional cell area occupied by PV⁺ cells in V1 cortical area.

In all tables, "NA" indicates unavailable data.