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Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes - data

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We synthesised cyanine dye derivatives and investigate their capability for mitochondrial targeting and organelle-specific delivery of different cargoes. NMR (*.fid), LCMS (*.d) and HRMS (*.pdf) spectra of synthesised compounds, confocal microscopy results (*.tif), and cell viability data (*.opj) are available here. Please refer to the publication (https://doi.org/10.1039/c9cc07931a) for nomenclature.


Funding

S CHEMY ESF TSAI KESS II (2016-10-01 - 2023-02-05); Tsai, Yu-Hsuan. Funder: Welsh European Funding Office, Tenovus Cancer Care:2014-2020 80815

Cleavable linkers for traceless delivery of therapeutics into cells (2016-09-01 - 2017-03-31); Tsai, Yu-Hsuan. Funder: Engineering and Physical Sciences Research Council

Design and in vitro characterisation of a novel modular targeting platform for cancer treatment (2016-10-01 - 2018-09-30); Tsai, Yu-Hsuan. Funder: Welsh Government, HEFCW

History

Specialist software required to view data files

NMR software (e.g. Mnova) for viewing .fid files; Agilent ChemStation for .d files; Origin for .opj files.

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