B(C6F5)3 Catalyzed Diastereoselective and Divergent Reactions of Vinyldiazo Esters with Nitrones: Synthesis of Highly Functionalized Diazo Compounds - data

We report a mild, transition-metal free, highly diastereoselective Lewis acid catalyzed methodology towards the synthesis of isoxazolidine-based diazo compounds, from the reaction between vinyldiazo esters and nitrones. Interestingly, the isoxazolidine products were identified to have contrasting diastereoselectivity to previously reported metal catalyzed reactions. Experimental procedures, full characterization of products, copies of ¹H, ¹³C, ¹⁹F NMR spectra, copies of mass spectra, and the X-ray crystallographic structures are included.

Research results based upon these daa are published at https://doi.org/10.1021/acs.orglett.2c04198