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A quantitative approach to predicting rate constants for aqueous racemization allows pointless stereoselective syntheses to be avoided

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posted on 2024-09-18, 10:26 authored by Andrew Ballard, Niklaas BuurmaNiklaas Buurma

This dataset contains 1H NMR data for arylglycine derivatives in phosphate buffers. This data was recorded as a function of time for samples kept at a constant temperature.

Analysis of the decrease of the relative integral for the proton on the stereogenic centre yields the kinetic data reported in https://doi.org/10.1002/ange.201709163.


Funding

Configuration stability (2007-10-01 - 2011-03-31); Buurma, Niek. Funder: AstraZeneca UK Ltd:KT094

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Specialist software required to view data files

To view the data files, software able to read datafiles generated by Bruker NMR instruments is required.

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